Trifluoromethylation and Fluorine Chemistry

This research sub-field focuses on the synthesis and application of trifluoromethyl groups and other fluorinated compounds in organic chemistry. The study of fluorine chemistry encompasses various methodologies, including catalytic reactions and novel synthetic routes that enhance the functionality and stability of organic molecules.

trifluoromethylation
fluorine chemistry
organic synthesis
catalysis
nucleophilic reactions
fluorinated compounds
synthetic methods
Palladium-catalyzed reactions

12,073 papers

Parent topic: Chemical and Material Sciences

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Sub-topics

Trifluoromethylation and Fluorine Chemistry

This research cluster focuses on synthetic methods and reactions involving trifluoromethylation and the formation of carbon-fluorine bonds. Key studies explore various strategies for incorporating trifluoromethyl groups into organic compounds, including catalytic processes and nucleophilic reactions with trifluoromethylated reagents.

13008 papers

Papers Over Time

192019401960198020002020

Top Papers

High-field FT NMR Application Of Mosher's Method. The Absolute Configurations Of Marine Terpenoids

1991 · 2,927 citations

Synthetic Methods For Compounds Having CF3–S Units On Carbon By Trifluoromethylation, Trifluoromethylthiolation, Triflylation, And Related Reactions

2014 · 978 citations

The Palladium-Catalyzed Trifluoromethylation Of Aryl Chlorides

2010 · 722 citations

Oxidative Trifluoromethylation And Trifluoromethylthiolation Reactions Using (Trifluoromethyl)trimethylsilane As A Nucleophilic CF3 Source

2014 · 680 citations

FI Catalysts For Olefin Polymerization—A Comprehensive Treatment

2011 · 576 citations

Synthetic Methods And Reactions. 141. Fluoride-induced Trifluoromethylation Of Carbonyl Compounds With Trifluoromethyltrimethylsilane (TMS-CF3). A Trifluoromethide Equivalent

1989 · 473 citations

Nucleophilic Trifluoromethylation Reactions Of Organic Compounds With (Trifluoromethyl)trimethylsilane

2000 · 387 citations

FI Catalysts: A New Family Of High Performance Catalysts For Olefin Polymerization

2002 · 380 citations

Combining Photoredox‐Catalyzed Trifluoromethylation And Oxidation With DMSO: Facile Synthesis Of α‐Trifluoromethylated Ketones From Aromatic Alkenes

2014 · 288 citations

Oxidative Trifluoromethylation Of Unactivated Olefins: An Efficient And Practical Synthesis Of α-Trifluoromethyl-Substituted Ketones

2013 · 267 citations

Palladium‐Catalyzed Oxidative Trifluoromethylation Of Indoles At Room Temperature

2011 · 222 citations

Structural Studies Of Semifluorinated N-Alkanes. 1. Synthesis And Characterization Of F(CF2)n(CH2)mH In The Solid State

1984 · 218 citations

New Stereospecific Synthesis Of Trisubstituted Olefins. Stereospecific Synthesis Of Farnesol

1967 · 218 citations

Rhodium-Catalyzed Synthesis Of Silafluorene Derivatives Via Cleavage Of Silicon−Hydrogen And Carbon−Hydrogen Bonds

2010 · 212 citations

Trifluoromethylation Of Various Aromatic Compounds By CF3I In The Presence Of Fe(II) Compound, H2O2 And Dimethylsulfoxide

2010 · 197 citations

Some New β-Diketones Containing The Trifluoromethyl Group1a

1950 · 194 citations

Catalytic, Highly Enantioselective Friedel−Crafts Reactions Of Aromatic And Heteroaromatic Compounds To Trifluoropyruvate. A Simple Approach For The Formation Of Optically Active Aromatic And Heteroaromatic Hydroxy Trifluoromethyl Esters

2001 · 189 citations

Palladium-Catalyzed Trifluoromethylthiolation Of Aryl C–H Bonds

2014 · 187 citations

Radical Acylfluoroalkylation Of Olefins Through N‐Heterocyclic Carbene Organocatalysis

2020 · 186 citations

Stereospecific Method To (E) And (Z) Terminal Fluoroolefins And Its Application To The Synthesis Of 2'-Deoxy-2'-Fluoromethylenenucleosides As Potential Inhibitors Of Ribonucleoside Diphosphate Reductase

1991 · 185 citations