Therapeutic Targeting in Cancer

Focusing on targeting cellular signaling pathways, this cluster evaluates novel therapeutic strategies aimed at enhancing cancer treatment effectiveness. It examines the role of pericytes and therapeutic peptides.

signaling pathways

therapeutics

cellular targeting

pericytes

blood-brain barrier

novel therapies

36,612 papers

Parent topic: Cancer Research and Treatment

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Papers Over Time

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Top Papers

Carbonic Anhydrases: Novel Therapeutic Applications For Inhibitors And Activators

2008 · 2,826 citations

Peptide Therapeutics: Current Status And Future Directions

2015 · 2,407 citations

Pericytes Regulate The Blood–Brain Barrier

2010 · 2,341 citations

Placebo-Controlled, Double-Blind, Prospective, Randomized Study On The Effect Of Octreotide LAR In The Control Of Tumor Growth In Patients With Metastatic Neuroendocrine Midgut Tumors: A Report From The PROMID Study Group

2009 · 2,136 citations

Identification Of A Unique TGF-β–dependent Molecular And Functional Signature In Microglia

2013 · 2,121 citations

Neuropilin-1 Is Expressed By Endothelial And Tumor Cells As An Isoform-Specific Receptor For Vascular Endothelial Growth Factor.

1998 · 2,103 citations

Angiogenesis: An Organizing Principle For Drug Discovery?

2007 · 1,995 citations

Inhibition Of SARS-CoV-2 Infections In Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

2020 · 1,895 citations

2001 · 1,857 citations

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped By The Local Microenvironment

2014 · 1,791 citations

Negative Regulation Of Transforming Growth Factor-Β By The Proteoglycan Decorin

1990 · 1,610 citations

Scope And Impact Of Financial Conflicts Of Interest In Biomedical Research

2003 · 1,566 citations

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary For Microglia Viability, Unmasking A Microglia Progenitor Cell In The Adult Brain

2014 · 1,502 citations

Therapeutic Peptides: Historical Perspectives, Current Development Trends, And Future Directions

2018 · 1,450 citations

Making Sense Of Latent TGFβ Activation

2003 · 1,442 citations

Clinical Translation Of Angiogenesis Inhibitors

2002 · 1,435 citations

NIH Consensus Conference. Impotence. NIH Consensus Development Panel On Impotence.

1993 · 1,395 citations

Targeting The TGFβ Signalling Pathway In Disease

2012 · 1,277 citations

GSK3 Takes Centre Stage More Than 20 Years After Its Discovery

2001 · 1,263 citations

Neuropilin-1 Is Expressed By Endothelial And Tumor Cells As An Isoform-Specific Receptor For Vascular Endothelial Growth Factor

1998 · 1,241 citations