Techniques for C−H Functionalization

This cluster examines diverse methodologies for the functionalization of carbon-hydrogen bonds. Focused studies evaluate catalytic systems that enable selective C−H activation and associated reaction mechanisms.

C−H functionalization
catalytic techniques
selective activation
reaction mechanisms
organic synthesis

143,151 papers

Parent topic: Advanced Catalysis and Material Science

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Papers Over Time

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Top Papers

A Modified Uronic Acid Carbazole Reaction.

1962 · 5,039 citations

A Modified Uronic Acid Carbazole Reaction

1962 · 4,509 citations

Rhodium-Catalyzed C−C Bond Formation Via Heteroatom-Directed C−H Bond Activation

2009 · 3,550 citations

An Overview Of N-heterocyclic Carbenes

2014 · 3,404 citations

The Halogen Bond

2016 · 3,217 citations

CH Bond Functionalization: Emerging Synthetic Tools For Natural Products And Pharmaceuticals

2012 · 2,787 citations

Activation Of C−H Bonds By Metal Complexes

1997 · 2,633 citations

The Wittig Olefination Reaction And Modifications Involving Phosphoryl-Stabilized Carbanions. Stereochemistry, Mechanism, And Selected Synthetic Aspects

1989 · 2,326 citations

Applications Of Palladium-Catalyzed C–N Cross-Coupling Reactions

2016 · 2,285 citations

Palladium- And Copper-Catalyzed Arylation Of Carbon−Hydrogen Bonds

2009 · 1,919 citations

Transition Metal-Catalyzed C–H Amination: Scope, Mechanism, And Applications

2017 · 1,846 citations

N-Heterocyclic Carbenes: A New Concept In Organometallic Catalysis

2002 · 1,831 citations

Direct Transition Metal-Catalyzed Functionalization Of Heteroaromatic Compounds

2007 · 1,577 citations

Transition-Metal-Catalyzed Addition Of Heteroatom−Hydrogen Bonds To Alkynes

2004 · 1,542 citations

Palladium Complexes Of N-Heterocyclic Carbenes As Catalysts For Cross-Coupling Reactions—A Synthetic Chemist's Perspective

2007 · 1,536 citations

Transition-Metal-Catalyzed Reactions In Heterocyclic Synthesis

2004 · 1,504 citations

Halogen Bonding And Other Σ-Hole Interactions: A Perspective

2013 · 1,450 citations

Highly Regioselective Arylation Of Sp3 C−H Bonds Catalyzed By Palladium Acetate

2005 · 1,409 citations

Catalytic Chemistry Of Heteropoly Compounds

1996 · 1,404 citations

Construction Of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications To The Synthesis Of Oxindole Alkaloids

2003 · 1,365 citations