Sequence Alignment and Structure Analysis

Research in this cluster deals with sequence alignment methods and their applications in structural biology. It aims to improve the understanding of evolutionary relationships and protein structures.

sequence alignment
structural biology
evolutionary relationships
bioinformatics tools
data analysis

229,673 papers

Parent topic: Genomic and Proteomic Research

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Papers Over Time

192019401960198020002020

Top Papers

Basic Local Alignment Search Tool.

1990 · 71,421 citations

The CLUSTAL_X Windows Interface: Flexible Strategies For Multiple Sequence Alignment Aided By Quality Analysis Tools

1997 · 34,238 citations

Clustal W And Clustal X Version 2.0

2007 · 24,634 citations

SHELXT– Integrated Space-Group And Crystal-Structure Determination

2015 · 22,550 citations

Crystallography & NMR System: A New Software Suite For Macromolecular Structure Determination

1998 · 17,449 citations

A Comprehensive Set Of Sequence Analysis Programs For The VAX

1984 · 16,476 citations

Refinement Of Macromolecular Structures By The Maximum-Likelihood Method

1997 · 14,824 citations

Potent And Specific Genetic Interference By Double-Stranded RNA In Caenorhabditis Elegans

1998 · 12,846 citations

UCHIME Improves Sensitivity And Speed Of Chimera Detection

2011 · 12,448 citations

Mfold Web Server For Nucleic Acid Folding And Hybridization Prediction

2003 · 11,616 citations

Improved Tools For Biological Sequence Comparison.

1988 · 11,048 citations

Conserved Seed Pairing, Often Flanked By Adenosines, Indicates That Thousands Of Human Genes Are MicroRNA Targets

2005 · 10,468 citations

SWISS-MODEL: Homology Modelling Of Protein Structures And Complexes

2018 · 9,823 citations

The Functions Of Animal microRNAs

2004 · 9,641 citations

Systematic Evolution Of Ligands By Exponential Enrichment: RNA Ligands To Bacteriophage T4 DNA Polymerase

1990 · 9,262 citations

Automated Docking Using A Lamarckian Genetic Algorithm And An Empirical Binding Free Energy Function

1998 · 8,856 citations

Primer3 On The WWW For General Users And For Biologist Programmers.

1999 · 8,838 citations

In Vitro Selection Of RNA Molecules That Bind Specific Ligands

1990 · 8,712 citations

A System Of Shuttle Vectors And Yeast Host Strains Designed For Efficient Manipulation Of DNA In Saccharomyces Cerevisiae.

1989 · 8,507 citations

Translating The Histone Code

2001 · 8,496 citations