Pharmacological Metabolism Research

This cluster focuses on the metabolism of drugs, including pharmacokinetics and the role of metabolic pathways in drug action and toxicity. Research includes studies on metabolic enzymes and their impact on drug efficacy.

pharmacology
metabolism
toxicology
pharmacokinetics
metabolic pathways

286,333 papers

Parent topic: Pharmacology and Toxicology

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Papers Over Time

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Top Papers

Inhibition Of Prostaglandin Synthesis As A Mechanism Of Action For Aspirin-like Drugs

1971 · 9,232 citations

Mechanism Of Sustained‐Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices

1963 · 3,856 citations

Comparison Of Upper Gastrointestinal Toxicity Of Rofecoxib And Naproxen In Patients With Rheumatoid Arthritis

2000 · 3,674 citations

Pharmacokinetics

1982 · 3,580 citations

Cytochrome P450 Enzymes In Drug Metabolism: Regulation Of Gene Expression, Enzyme Activities, And Impact Of Genetic Variation

2013 · 3,164 citations

Mortality And Morbidity In Patients Receiving Encainide, Flecainide, Or Placebo

1991 · 3,095 citations

Definition And Antagonism Of Histamine H2-receptors

1972 · 3,052 citations

Gastrointestinal Toxicity With Celecoxib Vs Nonsteroidal Anti-inflammatory Drugs For Osteoarthritis And Rheumatoid Arthritis

2000 · 2,949 citations

A Pharmacokinetic Analysis Program (Multi) For Microcomputer.

1981 · 2,928 citations

Graphical Evaluation Of Blood-to-Brain Transfer Constants From Multiple-Time Uptake Data

1983 · 2,875 citations

State‐of‐the‐Art Clinical Article: Pharmacokinetic/Pharmacodynamic Parameters: Rationale For Antibacterial Dosing Of Mice And Men

1998 · 2,675 citations

Niacin In Patients With Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

2011 · 2,615 citations

Adverse Drug Reactions As Cause Of Admission To Hospital: Prospective Analysis Of 18 820 Patients

2004 · 2,491 citations

Cardiovascular Risk Reduction With Icosapent Ethyl For Hypertriglyceridemia

2019 · 2,435 citations

A Physiological Approach To Hepatic Drug Clearance

1975 · 2,377 citations

International Union Of Pharmacology Classification Of Receptors For 5-Hydroxytryptamine (Serotonin).

1994 · 2,376 citations

Cardiovascular Events Associated With Rofecoxib In A Colorectal Adenoma Chemoprevention Trial

2005 · 2,306 citations

A Comparison Of The Two One-Sided Tests Procedure And The Power Approach For Assessing The Equivalence Of Average Bioavailability

1987 · 2,274 citations

Oral Sildenafil In The Treatment Of Erectile Dysfunction

1998 · 2,261 citations

Cytochrome P-450 Polymorphisms And Response To Clopidogrel

2009 · 2,226 citations