Murine Genetic Manipulation Techniques

This cluster focuses on methodologies for manipulating genes in murine models, a crucial aspect for studying genetic diseases and understanding gene function. The research includes techniques like gene knockout and high-throughput characterization systems for murine brains.

murine models
gene knockout
Cre reporting
genetic function
disease models

26,589 papers

Parent topic: Genomic and Proteomic Research

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Papers Over Time

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Top Papers

Construction Of Escherichia Coli K‐12 In‐Frame, Single‐Gene Knockout Mutants: The Keio Collection

2006 · 6,979 citations

Defective LPS Signaling In C3H/HeJ And C57BL/10ScCr Mice: Mutations In Tlr4 Gene

1998 · 6,138 citations

A Robust And High-Throughput Cre Reporting And Characterization System For The Whole Mouse Brain

2009 · 6,059 citations

Mice Deficient For P53 Are Developmentally Normal But Susceptible To Spontaneous Tumours

1992 · 4,763 citations

Generalized lacZ Expression With The ROSA26 Cre Reporter Strain

1999 · 4,498 citations

Genome-Scale CRISPR-Cas9 Knockout Screening In Human Cells

2014 · 4,427 citations

Motor Neuron Degeneration In Mice That Express A Human Cu,Zn Superoxide Dismutase Mutation

1994 · 3,916 citations

Heterozygous Embryonic Lethality Induced By Targeted Inactivation Of The VEGF Gene

1996 · 3,348 citations

Targeted Mutation Of The DNA Methyltransferase Gene Results In Embryonic Lethality.

1992 · 3,257 citations

A Global Double-Fluorescent Cre Reporter Mouse

2007 · 3,140 citations

Abnormal Blood Vessel Development And Lethality In Embryos Lacking A Single VEGF Allele

1996 · 3,106 citations

One-Step Generation Of Mice Carrying Mutations In Multiple Genes By CRISPR/Cas-Mediated Genome Engineering

2013 · 3,094 citations

Targeted Mutation Of The DNA Methyltransferase Gene Results In Embryonic Lethality

1992 · 2,921 citations

One-step Gene Disruption In Yeast.

1983 · 2,838 citations

Cre Reporter Strains Produced By Targeted Insertion Of EYFP And ECFP Into The ROSA26 Locus.

2001 · 2,809 citations

Designer Deletion Strains Derived fromSaccharomyces Cerevisiae S288C: A Useful Set Of Strains And Plasmids For PCR-mediated Gene Disruption And Other Applications

1998 · 2,744 citations

Efficient Genome Editing In Zebrafish Using A CRISPR-Cas System

2013 · 2,613 citations

A Genome-Wide Transgenic RNAi Library For Conditional Gene Inactivation In Drosophila

2007 · 2,419 citations

A Severe Combined Immunodeficiency Mutation In The Mouse

1983 · 2,377 citations

Mice Carrying Null Mutations Of The Genes Encoding Insulin-Like Growth Factor I (Igf-1) And Type 1 IGF Receptor (Igf1r).

1993 · 2,209 citations