Immunosuppressive Therapy Mechanisms

Research explores the pharmacological mechanisms and clinical applications of immunosuppressive therapies. Studies focus on treatment of autoimmune diseases, transplantation, and side effects of such therapies.

immunosuppressants
therapeutics
autoimmunity
transplantation
side effects

119,319 papers

Parent topic: Infectious Disease and Immunology

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Papers Over Time

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Top Papers

Calcineurin Is A Common Target Of Cyclophilin-Cyclosporin A And FKBP-FK506 Complexes.

1991 · 3,543 citations

Calcineurin Is A Common Target Of Cyclophilin-Cyclosporin A And FKBP-FK506 Complexes

1991 · 3,136 citations

Antiinflammatory Action Of Glucocorticoids — New Mechanisms For Old Drugs

2005 · 2,578 citations

Immunosuppression By Glucocorticoids: Inhibition Of NF-κB Activity Through Induction Of IκB Synthesis

1995 · 2,427 citations

Bortezomib Or High-Dose Dexamethasone For Relapsed Multiple Myeloma

2005 · 2,308 citations

Rituximab Versus Cyclophosphamide For ANCA-Associated Vasculitis

2010 · 2,306 citations

Wegener's Granulomatosis: Prospective Clinical And Therapeutic Experience With 85 Patients For 21 Years

1983 · 2,222 citations

International Consensus Statement On Preliminary Classification Criteria For Definite Antiphospholipid Syndrome: Report Of An International Workshop

1999 · 2,146 citations

Cyclosporine

1989 · 2,082 citations

Tafamidis Treatment For Patients With Transthyretin Amyloid Cardiomyopathy

2018 · 1,929 citations

Role Of Transcriptional Activation Of IκBα In Mediation Of Immunosuppression By Glucocorticoids

1995 · 1,776 citations

Commentary. Lysosomotropic Agents.

1974 · 1,749 citations

Biological Effects Of Cyclosporin A: A New Antilymphocytic Agent

1976 · 1,748 citations

Methotrexate And Cyclosporine Compared With Cyclosporine Alone For Prophylaxis Of Acute Graft Versus Host Disease After Marrow Transplantation For Leukemia

1986 · 1,746 citations

Identification Of Calcineurin As A Key Signalling Enzyme In T-lymphocyte Activation

1992 · 1,738 citations

Bortezomib Plus Melphalan And Prednisone For Initial Treatment Of Multiple Myeloma

2008 · 1,733 citations

The Mechanism Of Action Of Cyclosporin A And FK506.

1992 · 1,674 citations

Cyclosporine In Severe Ulcerative Colitis Refractory To Steroid Therapy

1994 · 1,645 citations

A Controlled Clinical Trial Of High-Dose Methylprednisolone In The Treatment Of Severe Sepsis And Septic Shock

1987 · 1,545 citations

Rituximab Versus Cyclophosphamide In ANCA-Associated Renal Vasculitis

2010 · 1,482 citations