Gene Regulation in Cancer

Research in this cluster focuses on the signaling pathways and transcriptional mechanisms regulating gene expression in cancer. It explores how these regulatory networks contribute to tumorigenesis.

gene regulation
cell signaling
transcription factors
cancer biology
gene expression
tumorigenesis

271,955 papers

Parent topic: Cancer Research and Treatment

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Papers Over Time

192019401960198020002020

Top Papers

edgeR: A Bioconductor Package For Differential Expression Analysis Of Digital Gene Expression Data

2009 · 33,980 citations

Simple Combinations Of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required For Macrophage And B Cell Identities

2010 · 11,104 citations

The Role Of Protein Kinase C In Cell Surface Signal Transduction And Tumour Promotion

1984 · 10,079 citations

Integrins: Versatility, Modulation, And Signaling In Cell Adhesion.

1992 · 8,833 citations

The Biology Of VEGF And Its Receptors

2003 · 8,301 citations

Inositol Trisphosphate, A Novel Second Messenger In Cellular Signal Transduction

1984 · 7,789 citations

G Proteins: Transducers Of Receptor-Generated Signals

1987 · 7,725 citations

Integrins: Versatility, Modulation, And Signaling In Cell Adhesion

1992 · 7,363 citations

Inositol Trisphosphate And Calcium Signalling

1993 · 7,237 citations

Integrins: Bidirectional, Allosteric Signaling Machines.

2002 · 7,221 citations

Toll-like Receptor Signalling

2004 · 7,213 citations

Studies And Perspectives Of Protein Kinase C

1986 · 6,673 citations

Signaling Recognition Events With Fluorescent Sensors And Switches

1997 · 6,371 citations

Untangling The ErbB Signalling Network

2001 · 6,051 citations

THE NF-κB AND IκB PROTEINS: New Discoveries And Insights

1996 · 5,970 citations

Jak-STAT Pathways And Transcriptional Activation In Response To IFNs And Other Extracellular Signaling Proteins

1994 · 5,875 citations

Rho GTPases And The Actin Cytoskeleton

1998 · 5,741 citations

Lipid Rafts And Signal Transduction

2000 · 5,588 citations

Hypoxia-inducible Factor 1 Is A basic-helix-loop-helix-PAS Heterodimer Regulated By Cellular O2 Tension.

1995 · 5,579 citations

Signal Integration In The Endoplasmic Reticulum Unfolded Protein Response

2007 · 5,511 citations