Fluorine in Medicinal Chemistry

This cluster is dedicated to the role of fluorine in drug design and development, investigating how fluorinated compounds influence biological activity and therapeutic efficacy. Research focuses on synthesis and structure-activity relationships.

fluorine chemistry

drug design

medicinal chemistry

therapeutic efficacy

synthesis

407,416 papers

Parent topic: Advanced Catalysis and Material Science

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Papers Over Time

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Top Papers

Glide: A New Approach For Rapid, Accurate Docking And Scoring. 1. Method And Assessment Of Docking Accuracy

2004 · 7,976 citations

Peptidotriazoles On Solid Phase: [1,2,3]-Triazoles By Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions Of Terminal Alkynes To Azides

2002 · 7,740 citations

In Situ Click Chemistry Generation Of Cyclooxygenase-2 Inhibitors

2017 · 7,483 citations

Fluorine In Medicinal Chemistry

2008 · 6,562 citations

Fluorine In Pharmaceuticals: Looking Beyond Intuition

2007 · 5,816 citations

Analysis Of The Structural Diversity, Substitution Patterns, And Frequency Of Nitrogen Heterocycles Among U.S. FDA Approved Pharmaceuticals

2014 · 4,748 citations

PubChem Substance And Compound Databases

2015 · 3,870 citations

The Many Roles For Fluorine In Medicinal Chemistry

2008 · 3,177 citations

Anthracyclines: Molecular Advances And Pharmacologic Developments In Antitumor Activity And Cardiotoxicity

2004 · 3,105 citations

Applications Of Fluorine In Medicinal Chemistry

2015 · 2,836 citations

Crystal Structure Of SARS-CoV-2 Main Protease Provides A Basis For Design Of Improved Α-Ketoamide Inhibitors

2020 · 2,644 citations

PubChem 2019 Update: Improved Access To Chemical Data

2018 · 2,410 citations

Synopsis Of Some Recent Tactical Application Of Bioisosteres In Drug Design

2011 · 2,383 citations

Next Generation Of Fluorine-Containing Pharmaceuticals, Compounds Currently In Phase II–III Clinical Trials Of Major Pharmaceutical Companies: New Structural Trends And Therapeutic Areas

2016 · 2,280 citations

Small-Molecule Library Screening By Docking With PyRx

2014 · 2,272 citations

Pyrrolidinyl-Spirooxindole Natural Products As Inspirations For The Development Of Potential Therapeutic Agents

2007 · 2,263 citations

The Medicinal Chemist’s Toolbox: An Analysis Of Reactions Used In The Pursuit Of Drug Candidates

2011 · 2,200 citations

PARP Inhibitors: Synthetic Lethality In The Clinic

2017 · 2,084 citations

The Influence Of Drug-Like Concepts On Decision-Making In Medicinal Chemistry

2007 · 2,052 citations

2014 · 2,007 citations