Drug Pharmacokinetics Evaluation

This research cluster covers the assessment of the pharmacokinetic profiles of drugs, including absorption, distribution, metabolism, and excretion. It seeks to develop tools and criteria for effective drug evaluation.

pharmacokinetics
evaluation
absorption
distribution
metabolism

35,874 papers

Parent topic: Pharmacology and Toxicology

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Papers Over Time

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Top Papers

SwissADME: A Free Web Tool To Evaluate Pharmacokinetics, Drug-Likeness And Medicinal Chemistry Friendliness Of Small Molecules

2017 · 10,276 citations

TCMSP: A Database Of Systems Pharmacology For Drug Discovery From Herbal Medicines

2014 · 3,323 citations

Updating The Beers Criteria For Potentially Inappropriate Medication Use In Older Adults

2003 · 2,055 citations

Pharmacogenomics — Drug Disposition, Drug Targets, And Side Effects

2003 · 1,566 citations

admetSAR: A Comprehensive Source And Free Tool For Assessment Of Chemical ADMET Properties

2012 · 1,547 citations

A BOILED-Egg To Predict Gastrointestinal Absorption And Brain Penetration Of Small Molecules

2016 · 1,545 citations

The Human Orphan Nuclear Receptor PXR Is Activated By Compounds That Regulate CYP3A4 Gene Expression And Cause Drug Interactions.

1998 · 1,480 citations

Predicting Drug Disposition Via Application Of BCS: Transport/Absorption/ Elimination Interplay And Development Of A Biopharmaceutics Drug Disposition Classification System

2005 · 1,174 citations

Risperidone Compared With New And Reference Antipsychotic Drugs: In Vitro And In Vivo Receptor Binding

1996 · 1,142 citations

[Imputation Of The Unexpected Or Toxic Effects Of Drugs. Actualization Of The Method Used In France].

1985 · 1,075 citations

The SIDER Database Of Drugs And Side Effects

2015 · 1,028 citations

A Quantitative Model For The In Vivo Assessment Of Drug Binding Sites With Positron Emission Tomography

1984 · 958 citations

Prediction Of Human Clearance Of Twenty-Nine Drugs From Hepatic Microsomal Intrinsic Clearance Data: An Examination Of In Vitro Half-Life Approach And Nonspecific Binding To Microsomes.

1999 · 923 citations

Fixed-Dose Combinations Improve Medication Compliance: A Meta-Analysis

2007 · 913 citations

Timing Of New Black Box Warnings And Withdrawals For Prescription Medications

2002 · 887 citations

Aripiprazole, A Novel Atypical Antipsychotic Drug With A Unique And Robust Pharmacology

2003 · 873 citations

Drug-Drug Interactions For Udp-Glucuronosyltransferase Substrates: A Pharmacokinetic Explanation For Typically Observed Low Exposure (Auci/Auc) Ratios

2004 · 860 citations

A Systematic Review Of The Associations Between Dose Regimens And Medication Compliance.

2001 · 830 citations

Network Pharmacology Databases For Traditional Chinese Medicine: Review And Assessment

2019 · 824 citations

Moving Beyond Rules: The Development Of A Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment Of Druglike Properties

2010 · 815 citations