Drug Interaction Studies

Research in this area investigates how different drugs may interact with each other and their potential implications on pharmacological effects. The focus is on understanding mechanistic approaches to drug interactions.

drug interactions
pharmacology
mechanisms
therapeutic implications
adverse effects

218,332 papers

Parent topic: Pharmacology and Toxicology

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Papers Over Time

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Top Papers

The Structure Of The Potassium Channel: Molecular Basis Of K + Conduction And Selectivity

1998 · 6,361 citations

Quantitative Analysis Of Dose-Effect Relationships: The Combined Effects Of Multiple Drugs Or Enzyme Inhibitors.

1984 · 5,718 citations

Some Quantitative Uses Of Drug Antagonists

1959 · 5,417 citations

Validation Of Open : Closed Arm Entries In An Elevated Plus-Maze As A Measure Of Anxiety In The Rat

1985 · 4,487 citations

Theoretical Basis, Experimental Design, And Computerized Simulation Of Synergism And Antagonism In Drug Combination Studies

2006 · 4,307 citations

A Sensitive And Reliable Locomotor Rating Scale For Open Field Testing In Rats

1995 · 3,941 citations

Simultaneous Analysis Of Families Of Sigmoidal Curves: Application To Bioassay, Radioligand Assay, And Physiological Dose-Response Curves.

1978 · 3,221 citations

Molecular Basis Of Agonism And Antagonism In The Oestrogen Receptor

1997 · 3,158 citations

A Rapid And Potent Natriuretic Response To Intravenous Injection Of Atrial Myocardial Extract In Rats

1981 · 3,099 citations

Pharmacology And Functions Of Metabotropic Glutamate Receptors

1997 · 2,908 citations

The Tail Suspension Test: A New Method For Screening Antidepressants In Mice

1985 · 2,893 citations

Lithium Amplifies Agonist-Dependent Phosphatidylinositol Responses In Brain And Salivary Glands

1982 · 2,795 citations

Cyclooxygenases 1 And 2

1998 · 2,701 citations

Molecular Physiology Of P2X Receptors

2002 · 2,636 citations

A Surface Glycoprotein Modulating Drug Permeability In Chinese Hamster Ovary Cell Mutants.

1976 · 2,569 citations

Chemical Inhibitor Of Nonapoptotic Cell Death With Therapeutic Potential For Ischemic Brain Injury

2005 · 2,509 citations

International Union Of Pharmacology. XXVII. Classification Of Cannabinoid Receptors

2002 · 2,481 citations

A Surface Glycoprotein Modulating Drug Permeability In Chinese Hamster Ovary Cell Mutants

1976 · 2,345 citations

The Use Of The Elevated Plus Maze As An Assay Of Anxiety-Related Behavior In Rodents

2007 · 2,281 citations

The Blood-Brain Barrier: Bottleneck In Brain Drug Development

2005 · 2,189 citations